Deaf Access to Healthcare

Modern medical professionals strive to provide culturally competent care; however, Deaf[1] culture remains overlooked. Common language and experience draw deaf individuals together as a cultural group. Ignorance about Deaf culture perpetuates barriers to holistic care in the medical setting. Deaf patients receive misdiagnoses, delayed treatment, and privacy breaches. Deaf culture understandably avoids healthcare and is characterized by numerous health disparities as a result. Obstacles hindering Deaf access to healthcare are directly opposed to the intended therapeutic relationship and holistic care. Increased awareness of Deaf culture is required to improve the Deaf’s access to healthcare. [1] The word deaf should be capitalized when referring to the people group or culture and lowercase when referring to the medical condition (Velonaki et al., 2015)

Swapping in lattice-based cell migration models

Cell migration is frequently modeled using on-lattice agent-based models (ABMs) that employ the excluded volume interaction. However, cells are also capable of exhibiting more complex cell-cell interactions, such as adhesion, repulsion, pulling, pushing, and swapping. Although the first four of these have already been incorporated into mathematical models for cell migration, swapping has not been well studied in this context. In this paper, we develop an ABM for cell movement in which an active agent can "swap" its position with another agent in its neighborhood with a given swapping probability. We consider a two-species system for which we derive the corresponding macroscopic model and compare it with the average behavior of the ABM. We see good agreement between the ABM and the macroscopic density. We also analyze the movement of agents at an individual level in the single-species as well as two-species scenarios to quantify the effects of swapping on an agent's motility

Cardiovascular risks of combined oral contraceptive use

Because of an increased risk of cardiovascular disease, the use of combined oral contraceptives (OCs) should be considered carefully in women who smoke and in those with hypertension or hyperlipidemia. (Strength of Recommendation: B, based on systematic reviews of case-control and cohort studies.) Combined OC use in patients with hypertension may increase the risk of peripheral arterial disease

Primary Care and the Perioperative Surgical Home

Our team partnered with UMass Memorial Medical Center’s Urology and Anesthesiology departments on a pilot patient-centered, physician-led, multidisciplinary team-based system of coordinated care for the surgical patient. The goals were to improve the patient experience, improve health care and reduce costs. Primary care physicians were surveyed to understand how surgical teams can better coordinate care with primary care. The results of the survey show that concise, useful communication about mutual patients is important to primary care physicians; there is no need for immediate follow-up appointments with primary care physicians unless necessary – appointments are recommended for two to four weeks after discharge; and defining the roles of primary care physicians and the surgeon is important

Swapping in lattice-based cell migration models

Cell migration is frequently modelled using on-lattice agent-based models (ABMs) that employ the excluded volume interaction. However, cells are also capable of exhibiting more complex cell-cell interactions, such as adhesion, repulsion, pulling, pushing and swapping. Although the first four of these have already been incorporated into mathematical models for cell migration, swapping is an interaction that has not been well studied in this context. In this paper, we develop an ABM to describe cell movement where an active agent can `swap' its position with another agent in its neighbourhood with a given swapping probability. We consider single-species and two-species systems. In both cases, we derive the corresponding macroscopic model and compare it with the average behaviour of the ABM. We see good agreement between the ABM and the macroscopic density. We also derive an expression for the cell-level diffusion coefficient in terms of the swapping probability and cell density. We conclude by showing applications of swapping by using the ABM to represent cell movement with proliferation and cell-cell adhesion.Comment: 32 pages, 12 figures, articl

Investigation of Superconducting Gap Structure in TbFeAsO0.9_{0.9}F0.1_{0.1} using Point Contact Andreev Reflection

Bulk samples of TbFeAsO$_{0.9}$F$_{0.1}$ (T$_{c}$(on) = 50K) were measured by point contact Andreev reflection spectroscopy. The spectra show unambiguous evidence for multiple gap-like features plus the presence of high bias shoulders. By measuring the spectra as a function of temperature with both gold and superconducting niobium tips, we establish that the gap-like features are associated with superconducting order parameter in this material. We discuss whether the well defined zero bias conductance peak that we observe infrequently is associated with a nodal superconducting order parameter.Comment: 11 pages, 5 figures, published versio

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

The lungs are generated by branching morphogenesis as a result of reciprocal signalling interactions between the epithelium and mesenchyme during development. Mutations that disrupt formation of either the correct number or shape of epithelial branches affect lung function. This, in turn, can lead to congenital abnormalities such as cystadenomatoid malformations, pulmonary hypertension or lung hypoplasia. Defects in lung architecture are also associated with adult lung disease, particularly in cases of idiopathic lung fibrosis. Identifying the signalling pathways which drive epithelial tube formation will likely shed light on both congenital and adult lung disease. Here we show that mutations in the planar cell polarity (PCP) genes Celsr1 and Vangl2 lead to disrupted lung development and defects in lung architecture. Lungs from Celsr1Crsh and Vangl2Lp mouse mutants are small and misshapen with fewer branches, and by late gestation exhibit thickened interstitial mesenchyme and defective saccular formation. We observe a recapitulation of these branching defects following inhibition of Rho kinase, an important downstream effector of the PCP signalling pathway. Moreover, epithelial integrity is disrupted, cytoskeletal remodelling perturbed and mutant endoderm does not branch normally in response to the chemoattractant FGF10. We further show that Celsr1 and Vangl2 proteins are present in restricted spatial domains within lung epithelium. Our data show that the PCP genes Celsr1 and Vangl2 are required for foetal lung development thereby revealing a novel signalling pathway critical for this process that will enhance our understanding of congenital and adult lung diseases and may in future lead to novel therapeutic strategies

A Uniform Analysis of the Ly-alpha Forest at z=0 - 5: V. The extragalactic ionizing background at low redshift

In Paper III of our series "A Uniform Analysis of the Ly-alpha forest at z=0 - 5", we presented a set of 270 quasar spectra from the archives of the Faint Object Spectrograph on the Hubble Space Telescope. A total of 151 of these spectra, yielding 906 lines, are suitable for using the proximity effect signature to measure J(\nu_0), the mean intensity of the hydrogen-ionizing background radiation field, at low redshift. Using a maximum likelihood technique and the best estimates possible for each QSO's Lyman limit flux and systemic redshift, we find J(\nu_0)= 7.6^+9.4_-3.0 x 10^-23 ergs s^-1 cm^-2 Hz^-1 sr^-1 at at 0.03 < z < 1.67. This is in good agreement with the mean intensity expected from models of the background which incorporate only the known quasar population. When the sample is divided into two subsamples, consisting of lines with z 1, the values of J(\nu_0) found are 6.5^+38._-1.6 x 10^-23 ergs s^-1 cm^-2 Hz^-1 sr^-1, and 1.0^+3.8_-0.2 x 10^-22 ergs s^-1 cm^-2 Hz^-1 sr^-1, respectively, indicating that the mean intensity of the background is evolving over the redshift range of this data set. Relaxing the assumption that the spectral shapes of the sample spectra and the background are identical, the best fit HI photoionization rates are found to be 6.7 x 10^-13 s^-1 for all redshifts, and 1.9 x 10^-13 s^-1 and 1.3 x 10^-12 s^-1 for z 1, respectively. This work confirms that the evolution of the number density of Ly-alpha lines is driven by a decrease in the ionizing background from z ~ 2 to z ~ 0 as well as by the formation of structure in the intergalactic medium. (Abridged)Comment: 71 LaTeX pages, 20 encapsulated Postscript figures, Accepted for publication in ApJ, Figure 4 available at http://lithops.as.arizona.edu/~jill/QuasarSpectra/ or http://hea-www.harvard.edu/QEDT/QuasarSpectra

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

Elevations in circulating glucose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe a signaling module that mediates the synergistic effects of these pathways on cellular gene expression by stimulating the dephosphorylation and nuclear entry of TORC2, a CREB coactivator. This module consists of the calcium-regulated phosphatase calcineurin and the Ser/Thr kinase SIK2, both of which associate with TORC2. Under resting conditions, TORC2 is sequestered in the cytoplasm via a phosphorylation-dependent interaction with 14-3-3 proteins. Triggering of the calcium and cAMP second messenger pathways by glucose and gut hormones disrupts TORC2:14-3-3 complexes via complementary effects on TORC2 dephosphorylation; calcium influx increases calcineurin activity, whereas cAMP inhibits SIK2 kinase activity. Our results illustrate how a phosphatase/kinase module connects two signaling pathways in response to nutrient and hormonal cues